To reduce temperature the physician is advised to push the administration of Anadol in 10 grain doses until the febrile condition is under control or until a maximum of 70 grains of the preparation has been ingested. The circular further states: “... in this lies the special value of ANADOL; there are no annoying by-effects; the stomach bears the remedy well and neither circulation, respiration, nor the nerve centers show the least disturbance.” As no evidence could be obtained concerning the composition of Anadol and, as the preparation is being brought to the attention of physicians by means of circulars in connection with the distribution of Noitol, it seemed worth while to take up its examination in the Association laboratory. Accordingly a trade package of the material which had passed into interstate commerce was purchased. Qualitative tests demonstrated the presence of sodium, a carbonate, caffein and acetanilid, the latter in considerable quantities. Analysis[99] indicated that the composition of the specimen examined is essentially as follows: Acetanilid 79 per cent. Caffein 1 per cent. Sodium bicarbonate 20 per cent. [99] Details of this analysis are published in the annual report for 1910 of the Chemical Laboratory of the American Medical Association. Since, according to the circular, it is permissible to prescribe 70 grains of this preparation within 2-1/2 hours, a patient thus treated would receive no less than 55 grains of acetanilid! In view of the numerous cases of poisoning due to the misuse of acetanilid (“The Harmful Effects of Acetanilid, Antipyrin and Phenacetin,” U. S. Dept. Agric., Bur. Chem., Bull. No. 126) the physician should be apprised of the composition of Anadol. [Editorial Note: The chemical investigations reported above emphasize once more the need of such an institution as the Association’s laboratory and again demonstrates the value of its work. At first sight it seems disheartening to find that physicians are so easily humbugged. Yet when it is remembered that it is impracticable for physicians either to analyze such products themselves or to go to the expense of having chemists do it for them, it is evident that the fault lies not so much with the physicians as with the conditions that make the exploitation of such frauds possible. It is on the public that the burden ultimately falls, for it is the layman who has to pay two dollars for a few cents’ worth of medicine. But--and this is far more serious--that the physician should be urged to dose his patient with an insidiously dangerous drug to a point far beyond the limits of safety, is little less than criminal. Yet so long as unknown medicinal products are prescribed just so long will this danger be a very real one.]--(_From the Journal A. M. A., May 21, 1910._) Anadol Declared Misbranded