The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2Council on Pharmacy and Chemistry (American Medical Association)
Science
The Propaganda for Reform in Proprietary Medicines, Vol. 1 of 2
Council on Pharmacy and Chemistry (American Medical Association)
Patent medicines
The question then arose as to the form in which the lithium and the
formaldehyd are present. The statements regarding its properties as
a urinary antiseptic and the fact that the preparation is said to
liberate formaldehyd slowly in the bladder point strongly to the
presence of hexamethylenamin.
Tests[102] were applied to demonstrate whether the formaldehyd was
present as a lithium compound, and if not, whether it existed in the
form of hexamethylenamin. By these the presence of hexamethylenamin
was proved and the absence of formaldehyd in other combinations
demonstrated. This fact alone shows that the preparation is
deliberately marketed under a false claim, and it shows further that
the analysis on the label is worthless. The quantitative method of
analysis demonstrated the presence of 5.51 gm. hexamethylenamin per
100 c.c. (25.15 grains per fluidounce).
[102] These appear in the annual report for 1908 of the Chemical
Laboratory of the American Medical Association; they were also
published in full in Jour. Am. Chem. Soc., September, 1908; an outline
of the analysis appeared in The Journal A. M. A., Aug. 29, 1908.
Besides the hexamethylenamin, Uriseptin contains lithium and a
benzoate. Concerning the latter nothing is said in the analysis, whose
worthlessness is again demonstrated. By quantitative methods Uriseptin
was found to contain lithium and a benzoate in such proportions as
would indicate that the lithium and the benzoate radicle exist as
lithium benzoate. This fact is further indicated by the claims made for
the preparation regarding its properties as a uric acid solvent, for
which purpose lithium benzoate is often used. Again, the demonstration
that the formaldehyd present is in combination as hexamethylenamin
precluded any possible chemical combination between lithium and
formaldehyd and adds another strong point in support of the conclusion
that the lithium and benzoic acid are in combination as lithium
benzoate.
CONCLUSION
By chemical analysis the active ingredients of Uriseptin are shown
to be hexamethylenamin, approximately 5.5 gm. per 100 c.c. (about 25
gr. to each fluidounce), and lithium benzoate, approximately 0.70 gm.
per 100 c.c. (about 11 grains to each fluidounce), neither of which
compounds is mentioned in the advertising matter on the label or in
the so-called “analysis” on the label. The statements concerning the
composition of Uriseptin are false and appear to be a deliberate
attempt to mislead physicians.
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