The Propaganda for Reform in Proprietary Medicines, Vol. 2 of 2Council on Pharmacy and Chemistry (American Medical Association)
Science
The Propaganda for Reform in Proprietary Medicines, Vol. 2 of 2
Council on Pharmacy and Chemistry (American Medical Association)
Patent medicines
From tissues it is obtained by extracting with warm alcohol and ether,
concentrating the extract, precipitating with acetone and repeating the
operations.
Pure lecithin is white, but the commercial preparations are
yellowish-brown wax-like solids, which are not soluble in water but
form milky emulsions which exhibit the myeline figures under the
microscope. The solubility in cold alcohol or ether is slight, but heat
aids it. Lecithins are not soluble in acetone. They are hygroscopic and
the water mixtures undergo decomposition on standing. They darken on
exposure to air and light.
The alcoholic solution is precipitated by platinum or cadmium
chloride. It is decomposed by alkalies with the formation of choline
and trimethylamine. The ash contains phosphoric acid. The different
lecithins contain from 3.84 to 4.12 per cent. of phosphorus and 1.73 to
1.86 per cent. of nitrogen. The ratio of nitrogen to phosphorus should
be at 1 to 2.21.
Lecithin is incompatible with alkalies; it should be kept in
well-stoppered bottles and should be protected from the light.
The content of lecithin (plus kephalin) in tissues is about as follows:
Per Cent.
Egg-yolk 8 to 12
Egg-white 0.1 to 0.2
Liver 2.0 to 3.0
Kidney 2.0 to 3.6
Lung 2.0 to 3.0
Pancreas 2.0 to 3.0
_Actions and Uses._--The lecithin preparations have been recommended
in many pathologic conditions, especially in malnutrition and sexual
debility. Moderate doses are said to bring about a marked retention of
nitrogen and phosphorus, but satisfactory proof of this is lacking. It
is extremely unlikely that the small doses which have been recommended
in pill or tablet form or in emulsions can have any perceptible action,
in view of the fact that many of our natural foods contain much greater
weights of available lecithins than the medicinal doses provide. There
is no good basis for the statement that the free lecithin has a greater
food value or is more readily assimilated than is the substance as
found in eggs or tissue. The reverse proposition is much more likely
to be true, especially when it is considered that the commercial
preparations are usually somewhat altered or decomposed in the process
of separation.
_Dosage._--Given by the mouth in the form of pills, tablets or
glycero-alcoholic emulsions. The amount of actual lecithin ingested
in this way is usually small because of the doubtful purity of the
original preparation. Several doses, as commonly administered, would
be required to furnish the amount of lecithin present in a small
egg.--(_From Reports of Council on Pharmacy and Chemistry, 1915,
p. 122._)
PROPRIETARY NAMES FOR LIQUID PETROLATUM
Report of the Council on Pharmacy and Chemistry
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