1872 1135 61 1873 1164 62 1874 1008 52 1875 1328 68 1876 1572 79 1877 2393 117 1878 1995 95 1879 1783 83 1880 2048 94 1881 2211 99 1882 2244 100 1883 1781 79 1884 1928 86 1885 1655 74 1886 1512 67 1887 1585 70 1888 1729 74 1889 1706 72 1890 1668 70 1891 1361 56 1892 1403 58 1893 1266 52 1894 1009 41 1895 435 17 1896 444 17 1897 298 12 1898 259 10 1899 339 13 1900 294 11 1901 736 28 1902 709 26 1903 399 15 1904 260 10 1905 204 7 Let us divide this mortality due to diphtheria into three groups (in Paris per 100,000 inhabitants):-- A. Before the discovery of serotherapy, from 1872 to 1888. B. During the period of experimentation with serotherapy, from 1889 to 1894. C. After the generalisation of serotherapy, from 1895 to 1905. We have then the following averages:-- ABSOLUTE. PER 100,000 INHABITANTS. Before serotherapy 1657 80 Intermediary period 1402 58 After serotherapy 398 15 And should these figures not seem sufficiently eloquent, let us set them forth in another form:-- ABSOLUTE MORTALITY. Before the discovery of serotherapy, 1888 1729 1st year of serotherapy, 1889 1706 2nd " " 1890 1668 3rd " " 1891 1361 4th " " 1892 1463 5th " " 1893 1266 6th " " 1894 1009 At this moment the practice of serotherapy, thanks to Roux, became general in Paris. 1st year, 1895--435. 2nd " 1896--444. During the next six years there were still hesitations and uncertainties as to the best method to be employed. The mortality during these six years, 1897-1902--439. Then the practice was definitely established. The mortality for the three years, 1903-1905--288.