The brain is made up of two entirely distinct substances. In the interior of the organ, and altogether concealed from view when a drawing of it is made, or the organ itself is exposed to observation, is _a white mass_ consisting of a multitude of fibres. These are simply crowds of nerve lines gathered together, led up from the extremities and trunk, or provided for intercommunication with the several parts of this central organ. Gathered all round about this, and constituting the external mass, on the summit, sides, and base of the brain, is a completely distinct substance known as _the grey matter_, folded up in wavings, twistings, or convolutions, enclosing myriads of cells from which nerve energy is discharged. These cells differ considerably in form and size, suggesting the possibility of distinct functions being assigned to cells of different structure, some being smaller and less intimately connected with those around, others so much larger and more important as to have suggested the name of pyramidal cells, and also having lines of connection between themselves and other parts much more numerous than in the case of the smaller cells. Every cell has a nucleus or central point, which is the centre of vitality, while the fibres which they send out, varying in number from one to four or five, establish connection between cells, or pass into the nerves proper. These cells are packed together in a soft glutinous substance, in the outer layer of which they are fewer in number; approaching the interior, they become more numerous; and they are both more abundant, larger in size, and more distinguished by the number of their protoplasmic[CS] fibres as they lie nearer to the mass of nerve fibres. In this crowd of nerve cells are the stores of nerve energy supplied to the nerve system, with every exercise of which molecular changes in the brain are believed to take place. On this account there must be regular and ample supply of nourishment for the brain, for which such provision has been made that, according to Haller's computation, one fifth part of the whole blood supply goes to the brain. [Illustration: HUMAN BRAIN, WITH CENTRES OF ELECTRIC EXCITATION.]