Furthermore the time in which it was founded had a potent and direct influence upon it. Alexander the Great died in 323 B.C., after carrying his arms to the banks of the Indus and enlarging the Greek world far beyond even his own vast dreams. The ideal state, even in the mind of Alexander’s great teacher Aristotle, was at this time thought to be one which corresponded closely to the actual Greek state, a community of limited size, whose free population should be all of the same stock, and one in which the manual toil should be performed by slaves. A sharp contrast to this was the mighty empire which Aristotle’s pupil carved in an incredible fashion out of Europe, Africa, and Asia. It is not to be wondered at that a philosophy, the principles of which were drawn from various Athenian schools, as I have just said, and which was developed by men like Zeno of Citium and Chrysippus of Soli in Cilicia should have a character which made it appeal to the enlarged and varied world of Hellenism, and to the Roman Empire which succeeded that of Alexander. The development of Stoicism corresponded to its eclectic origin. The system established by Zeno was enlarged and rounded out by Chrysippus. It was welcomed by the Romans in the second century B.C. when Panaetius of Rhodes transplanted the system to Rome. In the hands of its earliest leaders the school had held to a severe and uncompromising doctrine, not dissimilar to that of the Cynics. But Panaetius greatly modified this teaching, and accommodated the school to the other great philosophic systems of the time, especially to the doctrines of Plato and Aristotle; and thus he made Stoicism suited to the educated Roman world. Among his disciples he numbered many of the Roman aristocracy of the second century B.C., the most famous of whom were Laelius and the younger Scipio. That unyielding dogmatism of the older school which had paralleled Cynicism in teaching that between virtue and vice there was no intermediate position, that the philosopher was the perfectly virtuous man, and that he and the vicious were absolutely separated, was replaced by a doctrine of the possibility of gradual progress in virtue. Indeed some with good sense held that this was the most to which man could attain, that he could never hope to reach perfection, but that his duty was to accomplish a daily advance toward excellence. Panaetius did a great service in adapting Stoicism to life. A famous pupil of Panaetius was Posidonius of Apamea in Syria, who drew many Romans to hear him at his school in Rhodes, among them Cicero and Pompey. He carried still further the synthesis of Stoicism with Platonism and Aristotelianism, and by the astounding range of his learning and the brilliancy of his style acquired a large influence. He seems also to have given Stoicism a strong religious cast.