Various measures were taken to improve the general conditions of the city. Lepers were confined to a spot outside Ragusa called San Michele alla Cresta, which they were not allowed to leave. As elsewhere, they were regarded with feelings of horror mixed with superstitious awe. The earliest mention of them is in a small legacy in their favour dated 1295.[356] They probably made their first appearance at Ragusa at the time of the Crusades. We have already alluded to the great plague of 1348, and after that there were several outbreaks of the dread malady in Ragusa; they are recorded in Gradi’s history of the plagues at Ragusa, written “ad memoriam et terrorem cunctorum gentium.” In 1363 a second outbreak took place, a third in 1371, and a fourth in 1374. According to Gradi, the total number of victims in these four visitations amounted to 250 nobles and 25,000 commoners. Quarantine stations for persons coming from infected spots were established at Ragusavecchia and on the island rock of Mercana, but in spite of these precautions there was a fifth outbreak in 1391, which lasted six months, nearly all the nobles taking refuge at Gravosa. In 1397 a still more rigorous quarantine was established, but in 1400 the plague broke out afresh and carried off 2500 victims, and in 1401 it returned. The city then remained free from the scourge until 1416, when two months of plague caused the death of 3800 persons. It was imported from the East, it is said, by Paolo Gondola. In 1410 one Giacomo Godoaldo of Ferrara had been appointed official physician to the Republic, and seeing that his remedies were of little avail, he suggested in 1416 that plague patients should be isolated. The Senate agreed, and two houses in the suburb of Danče were set apart for them. When another outbreak occurred in 1422, the number of victims was very small, owing to these precautions.