Happily since then the long-coveted opportunity has been afforded me. In February 1887 I learned from Dr. Daniel Clark, Superintendent of the Provincial Asylum at Toronto, of the death of Thomas Neilly, a patient who had been under the doctor’s care for nearly two years. He was a native of Ireland, had served in the army, and was there noted as so inveterately left-handed that he was placed on the extreme left of his company, and allowed the exceptional usage of firing from the left shoulder. He could read and write, and was considered a man of good intelligence, till he attained his thirty-fourth year, when symptoms of insanity manifested themselves, and he was removed to the asylum, where he died. My colleague, Professor Ramsay Wright, accompanied me to the asylum on my learning of his death. The brain was removed and the two hemispheres carefully weighed. Cerebral disease manifested itself in the evidence of softening of the brain. But it was fully available for the special inquiry; and the result of the testing experiment was to place beyond doubt the preponderant weight of the right cerebral hemisphere. No comprehensive inductions can be based on a single case, but its confirmatory value is unmistakable at this stage of the inquiry; and thus far it sustains the conclusions previously arrived at, and justifies the assignment of the source of left-handedness to an exceptional development of the right hemisphere of the brain; with results of a greatly more comprehensive character, apparently affecting the whole functions ordinarily located in the opposite cerebral hemisphere. THE END _Printed by_ R. & R. CLARK, _Edinburgh_.