The special limitation of the researches of Dr. Guiseppe of Pisa to “the writing of left-handed persons” naturally directed his attention to this element of cerebration. “Clinical observation and pathological anatomy,” he remarks, “have clearly shown that in the foot of the second frontal convolution of the left cerebral hemisphere there is located a centre for the co-ordination and the memory of the movements of writing. The destruction of this centre produces _agraphia_, that is to say, inability to co-ordinate and remember the movements for writing. This graphic centre is situated on the left hemisphere in right-handed persons.” At the same time he is careful to assert that both in this writing-centre, and in that of the foot of the third frontal convolution, to which is assigned the co-ordination and memory of the movements for articulate speech: in the case of lesions impairing their powers, it has been found possible to stimulate the corresponding centres of the opposite hemisphere so as in more or less degree to perform their functions; just as the dormant left hand may be educated to take the place of the paralysed or amputated right hand. Dr. Guiseppe thus proceeds: “In left-handed persons the centres of the neuro-psychic factors of language are situate in the right hemisphere, as has been shown by well-studied cases. These persons, however, learn to write with the right hand and not with the left. And yet in their right hemisphere there is a potentiality which is very favourable for their education in the co-ordination and the memory of the movements for writing. Left-handed persons perceive that they could learn to write with greater facility with the left hand than with the right; but education succeeds in awaking and conveniently bringing into action in the left-hand sphere a latent cortical centre, which did not present so favourable a potentiality as that of the right hemisphere. The possibility of investigating what influence in left-handed persons practice with the right hand might develop in the left hemisphere for the explication of language, would certainly constitute a theme for important study” (_Archivio Italiano_, September 1890, pp. 306, 307).