After completing his school education Mr. Irvine became a student of the celebrated Dr. Cleghorn and proved to be an excellent surgeon and physician. On the completion of his studios he was appointed a surgeon on board a British man of war where he served for several years with great diligence and success. In 1763 he came to America and located at Carlisle, Pennsylvania. His eminent talents--professional acquirements and large experience, soon gained for him a liberal practice and proud reputation. Having no innate love for mother Britain, he was prepared to meet the fearful crisis of the American Revolution. There were numerous powerful influences in Pennsylvania adverse to war with England. There was a large number of the Society of Friends opposed to war under all circumstances, although quick to seize the benefits resulting from it. The Proprietary interests were very extensive and in favor of the crown. To rouse the people to resistance was a herculean task. In this work Mr. Irvine was active and successful. He was a member of the several preliminary conventions in the colony and became extensively influential in preparing the people for action. In January 1776 he was commissioned to raise and command a regiment which duty he performed promptly. On the 10th of the following June he joined Gen. Thompson's brigade with his troops near the village of Trois Rivieres. A disastrous attack was immediately made upon the vanguard of the British army stationed at that place. Gen. Thompson, Col. Irvine and near two hundred subordinate officers and privates were taken prisoners and sent to Quebec. An exchange was not effected until April 1778. On his return Gen. Irvine was put in command of the second Pennsylvania brigade and continued in that position until 1781. He was then transferred to Pittsburgh and assigned to the important and delicate duty of guarding the north-western frontier. It was important because difficult to obtain supplies and was menaced with British and Indians. It was delicate because there existed strong animosities between the first inhabitants of that region and those from Western Virginia who claimed the territory occupied. Under those circumstances the appointment was a high compliment from the sagacious Washington. The happy results were a strong eulogy upon the wisdom of both. Gen. Irvine succeeded in reconciling the two contending factions--brought order out of confusion and restored harmony and good feeling among those who had long been at variance. This augmented his strength against the enemy and increased the confidence of the people in that entire section of country. He was continued in that command until the war closed and the star spangled banner waved triumphantly over the United States of America.