There is no regular machinery for securing the permanent endowment of research, and it is always and everywhere a barely tolerated intruder. In the universities it crouches under the shadow of pedagogy, and snatches its time and its materials from the fragments which are left over when the all-important business of teaching the young what others have accomplished has been done. In commercial institutions it occasionally pursues a stunted career, subject to all the caprices of momentary commercial advantage and the cramped outlook of the "practical man." The investigator in the employ of a commercial undertaking is encouraged to be original, it is true, but not to be too original. He must never transcend the "practical," that is to say, the infinitesimal rearrangement of the preexisting. The institutions existing in the world which are devoted to research and, research alone can almost be counted on the fingers. The Solvay Institute in Brussels, the Nobel Institute in Stockholm, the Pasteur Institute in France, the Institute for Experimental Therapy at Frankfort, The Kaiser Wilhelm Institutes at Berlin, The Imperial Institute for Medical Research at Petrograd, the Biologisches Versuchsanstalt at Vienna, the Biological Station at Naples, the Royal Institution in London, the Wellcome Laboratories in England and at Khartoum, the Smithsonian, Wistar, Carnegie and Rockefeller Institutes in the United States; the list of research institutes of important dimensions (excluding astronomical observatories) is, I believe, practically exhausted by the above enumeration, and many of them are woefully undermanned and underequipped. At least two of them, the Solvay Institute wholly, and the Frankfort Institute for Experimental Therapy in part, owe their existence and continuance to scientific men, Solvay and Ehrlich, who have contrived to combine the pursuit of wealth and of science, and have dedicated the wealth thus procured to the science that gave it birth. In 1900 the value of the manufacturing industries in the United States which had been developed from patented scientific inventions was no less than $395,663,958 per annum,[4] corresponding to a capital value of about $10,000,000,000. It is impossible to arrive at any accurate estimate of the proportion of this wealth which finds its way back to science to provide equipment and subsistence for the investigator, who is creating the wealth of the future. But the capital endowment of the Rockefeller and Carnegie Institutes, the two wealthiest institutes of research in the world is, according to the 1914 issue of Minerva, only $29,000,000. The total income (exclusive of additions to endowments) of all the higher institutions of learning in the United States in 1913, was only $90,000,000, of which a minute percentage was expended in research. [4] 12th census, Vol. 10, Part 4.