COMMENTARY. There can be no doubt that it is the _Cucumis Colocynthis_, _Coloquintida_, or _Bitter Gourd_. It was used in medicine from the earliest times, being the κολοκύνθη ἀγρία of Hippocrates (De Mulieb. 621, ed. Föes), as Galen has explained. It does not occur, however, in the works of Celsus. Dioscorides gives an excellent account of it, recommending it as a powerful phlegmagogue and cholagogue, both when given by the mouth and in clysters; and as a gargle in toothache. He says it kills the fœtus _in utero_ when applied on a pessary. (iv, 175.) Our author’s account of it is copied from Galen. The Arabians treat of it more fully. See Avicenna (ii, 2, 127); Rhases (Cont. l. ult. i, 222); Serapion (c. 272); Mesue (De Simpl. 4); Averrhoes (Collig. v, 421); and Ebn Baithar (i, 331.) Avicenna is very precise in giving directions for the preparation of the medicine. His statement of its medicinal properties is so long that we cannot find room for it. He says it evacuates phlegm, bile, and perhaps blood from the intestines; that it is useful in dropsy, and that it is alexipharmic, in proof of which he refers to the report of a case of a person who had been stung by scorpions, and was immediately cured by it. But of all the authorities, Mesue is, perhaps, the one who treats of it most elaborately: he recommends it as purging phlegm and yellow bile, in cephalæa, hemicrania, epilepsy, apoplexy, vertigo, defluxion in the eyes, cold gout, and other affections of the joints; asthma, chronic cough, dyspnœa, &c. But, he adds, it is more especially useful in pituitous and flatulent colic, and in dropsy. For this purpose it may be administered by the mouth, in clysters and in suppositories. Applied _per vaginam_ it kills the fœtus. He directs its bad effects to be corrected by means of mastich, tragacanth, &c. He forbids it to be administered either in great heat or cold. Averrhoes ranks it with the strongest phlegmagogues, and recommends that its activity should be abated by almonds, tragacanth, fistics, &c. Ebn Baithar treats of it at very great length. Serapion says that, being a drastic purgative, it ought not to be given during the heat of summer, or cold of winter; for that, at these seasons, Hippocrates had forbid to administer purgatives. Pliny recommends it in injections for diseases of the intestines, kidneys, and loins. He says that an embrocation of it with oil cures pains of the spine and hip-joint, and is useful in jaundice when followed by oxymel. (H. N. xx, 7, 8.) Marcellus, the Empiric, says of it that it purges phlegm, yellow and black bile, when given with oxymel. (c. 30.) Ruffus Ephesius says of colocynth, that it purges phlegm and pure bile: in a word, he adds, it is useful in asthma, pleurisy, chronic headache, vertigo, and dimness of vision. (De Med. Purg.) Κόμαρος, Arbutus, _the Arbute Tree_, is of a sour quality, both the tree and its fruit, which is called memycœlon. It is hurtful to the stomach, and occasions headache.