COMMENTARY. There can be no doubt that they are two species of the Euphorbia or _Spurge_; probably the _E. Peplus_ and _E. Peplis_, that is to say, the petty spurge, and small purple sea spurge. These articles are frequently mentioned as drastic purgatives in the Hippocratic collection. (Epidem. vi., &c.) Ruffus Ephesius gives them the character of being safe phlegmagogues and cholagogues. (De Med. Purgant.) Dioscorides gives them the same characters. (iv, 65, 66.) They are also mentioned by Pliny (H. N. xx, 20), but are not noticed by Celsus. Galen gives their seed the character of purging, and at the same time of expelling flatulence. All the Greek authorities on the Mat. Med. down to Actuarius (Mat. Med. v), give them exactly the same character. The Arabians briefly say of them that they purge like the Tithymallé. See Avicenna (ii, 2, 103, 104.) We may be allowed to mention, that although the _E. Peplis_ and _Peplus_ be now excluded from our Dispensatory, they are still to be found in the shops of the apothecaries. We concur in the opinion thus stated by Boerhaave while treating of spurge root: “We have declined these rough medicines too hastily.” (Mat. Med.) See further Rutty (Mat. Med. 520.) Πέπερ, Piper, _Pepper_; its root resembles the costus in power. But the fruit of it, while yet germinating, forms the long pepper, being more humid and hot. But that which is as it were the unripe fruit is the white pepper, being more acrid than the black, because it is over-heated. Both are heating and desiccative. * * * * *