Mustapha Shatoor, an opium-eater of Smyrna, took daily three drachms of crude opium. The visible effects at the time were the sparkling eyes and great exhilaration of spirits. He found the desire of increasing his dose growing upon him. He seemed twenty years older than he really was—his complexion was very sallow—his legs small—his gums eaten away, and his teeth laid bare to the sockets. He could not rise without first swallowing half a drachm of opium. This case is detailed in the “Philosophical Transactions,” and for its veracity the Philosophers are responsible. Pouqueville says, “Always beside themselves, the Theriakis are incapable of work, they seem no more to belong to society. Toward the end of their career, they, however, experience violent pains, and are devoured by constant hunger, nor can their paregoric in any way relieve their sufferings; they become hideous to behold, deprived of their teeth, their eyes sunk in their heads, in a constant tremour, they cease to live long before they cease to exist. Heu Naetse, a native Celestial, in his address to the Sacred Emperor, the brother of the Sun and Moon, informs his imperial majesty, that “when any one is long habituated to inhaling opium, it becomes necessary to resort to it at regular intervals, and the habit of using it, being inveterate, is destruction of time, injurious to property, and yet dear to one even as life. Of those who use it to great excess, the breath becomes feeble, the body wasted, the face sallow, and the teeth black. The individuals themselves clearly see the evil effects of it, yet cannot refrain from it. It will be found on examination that the smokers of opium are idle, lazy vagrants, having no useful purpose before them.” Dr. Ball states, “that throughout the districts of China may be seen walking skeletons—families wretched and beggared by drugged fathers and husbands—multitudes who have lost house and home dying in the streets, in the fields, on the banks of the river, without even a stranger to care for them while alive, and when dead left exposed to view till they become offensive masses.”