Quite frequently, the first appearance of hemicrania in young girls coincides with the menarche. According to _Warner_, hemicrania made its first appearance: In 1 girl of 3 to 4 years. In 2 girls of 5 to 6 years. In 1 girl of 6 to 7 years. In 5 girls of 8 to 9 years. In 5 girls of 9 to 10 years. In 4 girls of 10 to 11 years. In 2 girls of 11 to 12 years. In 4 girls of 12 to 13 years. In 15 girls of 13 to 15 years. Toothache, according to _Holländer_, in the early days of puberty sometimes exhibits the twenty-eight-day type of menstruation. The same periodicity has been recorded in cases of vicarious bleeding from the gums in girls suffering from disturbance of the menstrual function. In the period of the menarche and before this period, chorea minor occurs, as a functional disturbance of the motor region of the nervous system, and especially in girls is it associated with the processes of the period of physical development. The statistical data supplied by a number of authors, _Hughes_, _Pye-Smith_, _Russ_, _Sée_, and _Steiner_, show that the proportion of boys to girls affected with chorea minor is 1 to 2.8, and that of all ages 49 per cent. of the cases occurred at the ages of 6 to 11 years, 29.8 per cent. at the ages of 11 to 13 years. In several cases, in quite young girls suffering from chorea, pathological changes were found in the genital organs. Thus, in 24 out of 27 girls from the age of 9 to 15 years affected with chorea, _Marie_ found the symptom-complex designated by _Charcot_ as _ovarie_. Ovarian tenderness was manifested on palpation, and always on that side on which the chorea had first manifested itself. _Leonard_ found in a girl aged eleven suffering from chorea, adhesion of the præputium clitoridis; after the separation of the prepuce, the chorea disappeared. As in respect of various nervous affections, so also in respect of various mental abnormalities, we witness at the time of the menarche numerous manifestations confirming the statement that, “no spinal reflex has such widely-opened and easily accessible paths of conduction toward the organ of mind, as the sexual reflex.” “The menstrual process,” continues _Friedmann_, “is the only bodily process in relation to which the organ of mind somewhat readily loses the remarkable stability of its equilibrium.”