In women it is during or after menstruation that the sexual appetite and consequently sexual hyperæsthesia are generally strongest, but there are many individual variations in this respect, and sometimes the opposite occurs. The effect of sexual hyperæsthesia is to direct the appetite toward any object capable of satisfying it. When the other sex is wanting, masturbation is generally resorted to. All mucous membranes (anus, mouth, etc.) and even inanimate objects may serve to satisfy the pathologically exalted appetite of such individuals. Men most distinguished in other respects may abandon themselves to the most foolish or abominable practices. _Animals are often used to satisfy the hyperæsthetic sexual appetite in both sexes. The healthy woman is not prone to such desires, unless of psychopathic taint. Men visit prostitutes, and become excited at the sight of every woman who is neither too old nor too repulsive. Some individuals of this kind are pursued night and day by erotic images, which may even become an obsession and a veritable torment._ A further degree of sexual hyperæsthesia is called _Satyriasis_ in man, and _nymphomania_ in woman. I have observed in women two very different varieties of sexual hyperæsthesia. In one, true nymphomania, the subjects are attracted toward man bodily and mentally with an elementary force; in these the whole brain follows the appetite in quite a feminine manner. Other women, on the contrary, are driven to masturbation by a purely peripheral excitation; they have erotic dreams with venereal orgasms which torment rather than please them; but they do not fall in love easily, and may have difficulty in the choice of a husband. Their mind alone remains feminine, full of tact and delicacy in its sentiments, while their lower nerve centers react in a more masculine and at the same time more pathological manner. There are many transitional forms between these two extremes. Sexual hyperæsthetics are often unhappy, and consult the physician for relief from the perpetual excitation which torments them. They attempt to master themselves and check their appetite in all ways, and are sometimes affected with nervous or mental depression. It is important, however, to recognize the fact, that many sexual hyperæsthetics remain quite fresh and active, and attain an advanced age, provided they escape alcohol and venereal disease.