The time will come when most of our manufactures can be procured from the northern or middle states cheaper than from Europe, and when those states will also furnish a larger market for the products of the south. The time has already come when cotton, and rice, and tobacco, if that pernicious weed shall always constitute one of man's artificial wants, can be procured more cheaply from the southern states than elsewhere; and though there is not, within the present limits of the United States, as much land adapted to the cane as will supply its future inhabitants with sugar, without that increase of price which must greatly diminish its rate of consumption, yet the trade in this useful commodity will not therefore be less important, either to the states which sell, or those which purchase it. This commercial intercourse will be greatly extended by the numerous canals and rail roads, which are destined to intersect our country in every direction. By the greater cheapness of transportation, the commerce will be extended, not only because more distant points will be brought into connection, but also because there will be a greater number of articles which may be advantageously transported. All the canals and rail roads from one state to another, which shall be sufficiently used to compensate for their construction, will be so many sinews to knit together our wide spread and diversified republic. New York and Pennsylvania have already thus bound themselves to the west. Maryland and Virginia, and, without doubt, Georgia and the Carolinas, will follow the example. When we shall be thus connected by the golden chain of mutual interests instead of the iron fetters of power, and by that homogeneousness of manners which an increased intercourse will produce, what will be likely to effect a separation? Let us suppose any state, considering itself aggrieved by some measure of the federal government, was to withdraw herself from the confederacy, and that the other states were to acquiesce in her course, either because they felt no interest in the matter, or because they were willing to surrender up those interests to a claim of right. It can scarcely be doubted that such seceding state would find the disadvantages of its new situation so great, surrounded by rival and hostile and taunting neighbors--attended with so much contingent danger and certain expense, that after the first irritation had passed away, it would sue to be re-admitted.