atmosphere has had the cholera, more or less, for thirty years, and will continue to have it until there occurs a geological change in many portions of the earth; and from the atmosphere the disease has been, and is, communicated epidemically to the predisposed potato plant, and also to the human system." A late English writer remarks, that "certain diseases prevail at the approach of the equinoxes." * * * * * * Transcriber's note: Minor typographical errors have been corrected without note. Irregularities and inconsistencies in the text have been retained as printed. Unmatched double quotation marks occur in numerous places, particularly near the end of the text. No attempt was made to open or close these quotations unless the location of the missing double quotation mark was apparent.