Inflamed spots now begin to appear on different parts of the hands of the domestics employed in milking, and sometimes on the wrists, which run on to suppuration, first assuming the appearance of the small vesications produced by a burn. Most commonly they appear about the joints of the fingers, and at their extremities; but whatever parts are affected, if the situation will admit, these superficial suppurations put on a circular form, with their edges more elevated than their centres, and of a colour distantly approaching to blue. Absorption takes place, and tumours appear in each axilla [arm-pit]. The system becomes affected, the pulse is quickened; shiverings, succeeded by heat, general lassitude and pains about the loins and limbs, with vomiting, come on. The head is painful, and the patient is now and then even affected with delirium. (P. 3.) And Jenner might have added, with convulsions. Having drawn this alarming picture of the effects of Cowpox, he interposes-- These symptoms arise principally from the irritation of the sores, and not from the primary action of the vaccine virus upon the constitution. (P. 5.) If Cowpox meant all this, some might prefer, at least, the risk of Smallpox; hence the judicious explanation--the irritation of the sores, and not the poison in the blood, was the cause of the distressing symptoms. Jenner went on-- These symptoms, varying in their degrees of violence, generally continue from one day to three or four, leaving ulcerated sores about the hands, which, from the sensibility of the parts, are very troublesome, and commonly heal slowly, frequently becoming phagedenic, like those from whence they sprang. During the progress of the disease, the lips, nostrils, eyelids, and other parts of the body, are sometimes affected with sores; but these evidently arise [How evidently?] from their being heedlessly rubbed or scratched with the patient’s infected fingers. (P. 5.) It was this serious disease, this communicated Cowpox, which the subjects of the foregoing Cases were assumed to have passed through; and Jenner, in conformity with the opinion of the dairies, held that they were thereby rendered proof against Smallpox. Whilst his Twelve Cases make a show of inquiry, they bear no trace of extensive or critical research. In the general inoculations then prevalent, those who had undergone Cowpox were not treated as protected (as were those who had had Smallpox) but were “cut” with their neighbours--as, in Case xii., were the eight cowpoxed paupers of Tortworth. Yet Jenner was at no pains to collect and set forth the evidence of other Gloucestershire practitioners, who, in the course of duty, must have known as much of Cowpox as himself, and might have set scores of Cases alongside his perfunctory dozen. Having perused Jenner’s description of Cowpox, let us now turn to his account of its origin. GENERATION OF COWPOX IN HORSEGREASE.