Jenner’s references to the good effects of vaccination in London were curiously inconsistent. That vaccination in which he professed to rejoice was chiefly the work of Dr. John Walker, whose practice he had denounced as so widely at variance with what he considered correct, that even the wreck of the Royal Jennerian Society was not thought too heavy a price to pay for deliverance from complicity with him. The London Vaccine Institution, established in 1806 by Walker and his friends, was responsible for the large majority of vaccinations effected in the metropolis. Walker was a pure enthusiast, of boundless energy, with a craze for vaccinating. Adverse results had no effect upon him: he did not deny, but simply did not recognise them, and held on prophesying and practising with mechanical persistency. Nevertheless, he ran aground. The income of the Institution had dwindled to less than £100 a year when Andrew Johnstone, a Cumberland man, a school-fellow of Walker, came to his assistance. With a commercial eye he surveyed the situation. He perceived that though vaccination had fallen into disrepute, there remained many believers who only required stirring up and solicitation to provide funds to keep Walker going and to yield the collector a satisfactory commission. As the Royal Jennerian Society had ceased to exist for any active purpose in 1810, nothing remaining “but a Patronage, a Presidency, and an unorganised body of Subscribers and Governors,” it occurred to him that it would be good policy to annex these to the revived enterprise, and in due course a union was effected, and the LONDON VACCINE INSTITUTION AND ROYAL JENNERIAN SOCIETY became the title to conjure with. An attempt was made to secure Jenner for President, but that was too bold a stroke. He thus answered the application-- CHELTENHAM, _3rd September, 1813_. Although it must be evident that every institution which has for its object the extension of Vaccine Inoculation, must have my best wishes for its success, yet, for reasons which on reflection must be obvious, you must see the impossibility of my accepting the offered appointment.