It has been said that in his foreign policy John II. followed in the course set before him by John the Great. With the great monarchs then ruling in Spain, Ferdinand of Aragon and Isabella of Castile, he consistently remained on friendly terms, and in 1490 his only legitimate son, Affonso, was married to Isabella, eldest daughter of these sovereigns. The death of this son in the following year, without leaving children, was a terrible blow to him, but he nevertheless maintained his friendship with Ferdinand and Isabella, and in 1494 concluded the Treaty of Tordesillas with them. By this treaty, which was confirmed by a Bull, issued by Pope Alexander VI., the limit of the future possessions of the Spaniards and Portuguese in the regions explored and discovered by their mariners was 370 leagues west of Cape Verde, and it was agreed that the Spaniards were to have full right to all lands discovered to the west of this line, and the Portuguese to all to the south and east. What a curious commentary this treaty forms on that of Cella Nova, concluded three hundred years before between Affonso Henriques of Portugal and Ferdinand of Leon, by which these two monarchs agreed to take the course of the Guadiana as the line to separate their future conquests from the Moors. Both nations had now developed; the energies of both, heightened by the long struggle with the Mohammedans, sought for fresh fields, and expanding far beyond the boundaries of Europe, were to prove themselves, in the one case in Mexico and Peru, and in the other in India and the countries of the East.