Jews or Moslems. For this decree of banishment passed against law-abiding Portuguese citizens, Emmanuel had his reward, for he was married to the Infanta Isabella in 1497. But the curse of the Jews followed him, and he never sat upon the throne of Spain. Whilst the royal bride and bridegroom were passing through the cities of Castile in a state progress as heirs to the thrones of Spain, Queen Isabella fell ill, and died at Toledo on August 24, 1498. She left an infant son, Dom Miguel, at whose birth she had died, but he did not survive to realize the hopes of his father, and died in 1500. Even these two deaths did not put an end to Emmanuel’s schemes, and in the same year 1500, he married the Donna Maria of Castile, the sister of his deceased wife. This marriage was not so likely to promote his success as the first; for whereas the Infanta Isabella was the eldest daughter of Ferdinand and his queen, the Infanta Maria was but the third daughter, and the daughter between them, the Infanta Joanna, had a son who, as the legitimate heir of his grandparents, was to succeed to thrones of Spain and eventually become the Emperor Charles V. By his second wife, Emmanuel had no less than six sons, but what has been called the “curse of the Jews” pursued them, and his descendants soon failed in the direct line. Even to the last, the same wild fancy possessed him, and in 1518, the year after his second wife’s death, he married again, and this time also with a view of succeeding Charles V., for he married his own niece, the sister of the Emperor. She survived him, and afterwards married Francis I. of France.