Vomiting is of the so-called ‘cerebral’ type. It is of frequent occurrence, generally irrespective of ingestion of food and seldom preceded by any nausea and retching. The attacks are often associated with exacerbation of headache, and more rarely with some slight elevation of temperature. The more severe the vomiting the more likely is the tumour to be subtentorial in position. =Alterations in pulse, respiration, and blood-pressure.= In the early stages there is but little alteration in pulse and respiration. Later on, the increasing intracranial pressure acts as a stimulus on the vagus and vaso-motor centres, the pulse becomes slowed and the blood-pressure raised. When the pressure is considerable, the slow pulse and deep, even stertorous, respiration evidence the effect produced on the medullary centres. In the terminal stages the imminent exhaustion of these centres is heralded by progressive acceleration of the pulse, by great fall in blood-pressure, and by the advent of Cheyne-Stokes respiration. The more marked the alterations in pulse and respiration the more likely is the tumour to be subtentorial in position. =Alterations in temperature.= The temperature tends to remain subnormal throughout the progress of the case, except during the terminal stages when pyrexia is often observed. Occasional elevations of temperature during the course of the illness may be explained by transient attacks of ependymitis or cerebritis. Differences of temperature on the two sides of the body may occasionally be observed, especially when the tumour involves the basal ganglia. II. LOCALIZING SYMPTOMS (_A_) =To the non-excito-motor frontal region (anterior frontal).= _Headache_ tends to be localized to the frontal region, _vomiting_ is seldom a conspicuous feature, and _optic neuritis_ is not only rather later in development, but also less progressive than when the tumour is placed in other situations. If the tumour occupies the orbital aspect of the lobe, primary optic atrophy (from pressure) may be existent on the affected side with optic neuritis of the contralateral fundus. The _mental condition_ is often profoundly altered and, according to some writers, more especially so when the tumour is situated on the left side. The quality of mental change varies considerably in individual cases. In some there is an attitude of general suspicion, the patient following all points in his general examination with a curious air of suspicion, in others moral perversion is the rule, whilst in a third group of cases a state of elation and exhilaration is the predominant feature, a condition which, as previously stated, is said to be pathognomonic of a tumour frontally situated. _Anosmia_--uni- or bi-lateral--may be present, but, on account of the general condition of the patient, considerable difficulty is experienced in endeavouring to demonstrate the existence of this symptom. [Illustration: FIG. 68. THE CORTICAL MOTOR AND SENSORY AREAS.]