The immediate cause of the infirmities of age, or of the progress of life to death, has not yet been well ascertained. The answer to the question, why animals become feeble and diseased after a time, though nourished with the same food which increased their growth from infancy, and afterwards supported them for many years in unimpaired health and strength, must be sought for from the laws of animal excitability, which, though at first increased, is afterwards diminished by frequent repetitions of its adapted stimulus, and at length ceases to obey it. 1. There are four kinds of stimulus which induce the fibres to contract, which constitute the muscles or the organs of sense; as, first, The application of external bodies, which excites into action the sensorial power of irritation; 2dly, Pleasure and pain, which excite into action the sensorial power of sensation; 3dly, Desire and aversion, which excite into action the power of volition; and lastly, The fibrous contractions, which precede association, which is another sensorial power; see Zoonomia, Vol. I. Sect. II. 13. Many of the motions of the organic system, which are necessary to life, are excited by more than one of these stimuli at the same time, and some of them occasionally by them all. Thus respiration is generally caused by the stimulus of blood in the lungs, or by the sensation of the want of oxygen; but is also occasionally voluntary. The actions of the heart also, though generally owing to the stimulus of the blood, are also inflamed by the association of its motions with those of the stomach, whence sometimes arises an inequality of the pulse, and with other parts of the system, as with the capillaries, whence heat of the skin in fevers with a feeble pulse, see Zoonomia. They are also occasionally influenced by sensation, as is seen in the paleness occasioned by fear, or the blush of shame and anger; and lastly the motions of the heart are sometimes assisted by volition; thus in those who are much weakened by fevers, the pulse is liable to stop during their sleep, and to induce great distress; which is owing at that time to the total suspension of voluntary power; the same occurs during sleep in some asthmatic patients.