April 21: Urine free from sugar. April 22: Urine free from sugar. 1 gram caffein given in the afternoon. April 23: 9 a. m., dog was very thirsty, drank a large quantity of water, urine did not reduce Fehling's solution. April 24: 2.30 p. m., 1 gram caffein, no sugar in urine. April 25: 1 gram caffein administered. April 26: Weight, 10.6 kilos, urine collected in the morning, no sugar; 4.10 p. m., 1.5 grams caffein. April 27: 1.5 grams caffein; 1.30 p. m., diet as before, no sugar in urine. April 28: Weight, 10.2 kilos, no caffein, no sugar in urine. April 30: Weight, 10.4 kilos, no sugar in urine; 4.20 p. m., 2 grams caffein. May 1: Urine examined, sugar absent, weight 10 kilos, vomited, sick, tremors observed, drank 500 cc water at one time, appetite poor. May 2: No caffein, drank 150 cc water. May 3: Urine, no sugar, moderate quantity of albumen present; 12 noon, 2 grams caffein given by mouth, weight 10.3 kilos; 2 p. m., urine, sugar negative, condition of dog good, no symptoms of caffein intoxication. May 4: 10 a. m., about 10 cc thick, dark-colored mucilaginous urine found in collecting bottle; albumin a little more than a trace, decidedly less than on May 3, no sugar, condition of dog pretty good except for slight muscular tremors; 4 p. m., 2 grams caffein by mouth (as usual). May 5: Urine not examined, no symptoms; 4 p. m., 2 grams caffein. May 6: Urine not examined; 2.30 p. m., 2.5 grams caffein given by mouth; 4 p. m., slight tremor, no other symptoms. May 7: No examination of urine, no symptoms observed; 4 p. m., 2.5 grams caffein. May 8: 9 a. m., found dead, urine collected since last dose of caffein was given did not contain any sugar or albumin, the amount of caffein fed to this dog was 18 grams in 18 days. _Autopsy_: Post-mortem examination showed marked enteritis with hemorrhagic spots on the mucosa; liver and kidneys congested and dark colored; lungs congested; thyroid gland was greatly enlarged and congested. _Dog 28_.