May 23: Weight, 7.5 kilos; no caffein. May 24: 0.75 gram caffein; tremors very marked. May 25: No caffein. May 26: 0.75 gram caffein. May 27: 0.75 gram caffein. May 28: 0.75 gram caffein. May 29: 1 gram caffein in two doses of 0.75 and 0.25 gram. May 30: No caffein. May 31: No caffein; meat diet exclusively. June 1: No caffein; meat diet exclusively. June 2: No caffein; no sugar, no albumin in urine. June 3: Weight, 7.6 kilos; 0.75 gram caffein; no sugar in urine. June 4: Weight, 7.3 kilos; 0.75 gram caffein; no sugar in urine. June 5: Weight, 7.5 kilos; 0.8 gram caffein; drank 500 cc water; ate 200 grams meat. June 6: Weight, 7.4 kilos; 0.8 gram caffein; 500 cc urine; drank 500 cc water; ate 200 grams meat; no symptoms. June 7: Weight, 7.7 kilos; 0.8 gram caffein 10 a. m.; 400 cc urine, 500 cc water, 200 grams meat. June 8: Weight, 7.5 kilos; 0.9 gram caffein, 450 cc urine, 1 p. m.; 200 grams meat, 500 cc water. June 9: Weight, 7.6 kilos; 0.9 gram caffein, 1 p. m.; 500 cc water, 200 grams meat and bone dust; diarrhea and restlessness all afternoon. June 10: Weight, 7.6 kilos; 1 gram caffein, 500 cc water, 200 grams meat, 480 cc urine. June 11: Weight, 8 kilos; 1 gram caffein, 470 cc urine, 500 cc water, 200 grams meat. June 12: Weight, 7.8 kilos; 1 gram caffein, 710 cc urine, 500 cc water, 200 grams meat. June 13: 450 cc urine, 500 cc water, 300 grams meat. June 14: Weight, 7.9 kilos; 1.2 grams caffein, 500 cc water, 300 grams meat, 490 cc urine. June 15: Weight 7.8 kilos, 500 cc water, 300 grams meat, 550 cc urine. June 16: Weight 8.0 kilos, 1.2 gram caffein, 500 cc water, 300 grams meat, bone dust added to check diarrhea. June 17: 500 cc water, 300 grams meat, 450 cc urine, diarrhea continues, bone dust added. June 18. Weight 7.8 kilos, 1.3 gram caffein, 300 grams meat, 500 cc water, 300 cc urine. June 19: Dog very thirsty, drank 1 liter of water and ate 350 grams of meat; 960 cc urine passed during the past 24 hour. June 21: Weight 7.5 kilos, 1.5 grams caffein given at 10 a. m. At 2 p. m. convulsions and death. This dog received a total of 21.15 grams caffein in 25 doses during a period of 35 days, which amounts to an average of 85 mg per kilo daily. _Dog 19._ _Female fox terrier._ May 13: Weight 6.4 kilos. Diet consisted of rice, 100 grams; sugar, 100 grams; and a sufficient quantity of meat and cracker meal to give flavor to the food. Examination of the urine showed a trace of albumin but no sugar. The urine was acid to litmus. Two days later the urine was alkaline to litmus. There was still a small amount of albumin but no sugar. May 17: 0.5 gram caffein was given by mouth. Examination of the urine collected the next day still showed the presence of albumin and the absence of reducing substances. The dog had tremors. Caffein was, therefore, not administered. May 19: 0.5 gram caffein was given by mouth.