The urine was examined before and after the administration of caffein. No symptoms were observed after the administration of caffein (5 doses in 11 days), nor was albumen or sugar found in the urine after any of the experiments on this rabbit. _Autopsy_: Pyloric mucosa exhibited several ulcers; small intestines showed slight inflammation; liver deeply congested; kidneys showed marked inflammation of cortex; other organs practically normal. _Rabbit 181._ _Diet, carrots September 29-October 17, then oats._ ---------+---------+---------- Date. | Weight. | Caffein | |per kilo. ---------+---------+---------- | _Grams._| _Gram._ Oct. 4 | 1,425 | 0.105 Oct. 5 | 1,450 | .100 Oct. 6 | 1,270 | .100 Oct. 7 | 1,210 | .100 Oct. 8 | 1,375 | .130 Oct. 9 | 1,305 | .153 Oct. 11 | 1,370 | 0.175 Oct. 13 | 1,385 | .180 Oct. 16 | 1,345 | .200 Oct. 17 | 1,030 | Oct. 18 | 1,230 | Oct. 20 | 1,215 | ---------+---------+---------- Rabbit was markedly emaciated and weak. No albumen or sugar found in the urine as a result of caffein feeding. _Rabbit 182._ _Diet of carrots from September 29._ Received caffein subcutaneously as follows: ---------+---------+----------- Date. | Weight. | Caffein | |per kilo. ---------+---------+----------- | _Grams._| _Gram._ Oct. 4 | 1,765 | 0.100 Oct. 5 | 1,880 | .100 Oct. 6 | 1,750 | .100 Oct. 7 | 1,710 | .100 Oct. 8 | 1,685 | .135 Oct. 9 | | .150 Oct. 11 | 1,605 | .174 ---------+---------+---------- October 12: 11 a. m., 23 hours after caffein was given, convulsions with recovery; rabbit died at 1.30 p. m. No sugar was found in the urine at any time after the administration of caffein. Albumen was present only in one specimen. _Rabbit 183._ _Diet of carrots from September 29._ Received caffein subcutaneously as follows: ---------+---------+---------- Date. | Weight. | Caffein | |per kilo. ---------+---------+---------- |_Grams._ | _Gram._ Oct. 4 | 1,385 | 0.100 Oct. 5 | 1,460 | .100 Oct. 6 | 1,385 | .100 Oct. 7 | 1,240 | .122 Oct. 8 | 1,310 | 0.153 Oct. 9 | 1,390 | .142 Oct. 11 | 1,390 | .187 ---------+---------+--------- October 12: 9 a. m., found dead. No albumen was found in the urine. Only one sample contained sugar. _Rabbit 123._ _White, female._ _Diet, oats._ Received caffein subcutaneously as follows: ---------+---------+--------- Date. | Weight. | Caffein | | per | | kilo. ---------+---------+--------- |_Grams._ |_Grams._ Apr. 14 | 2,350 | 42 Apr. 16 | 2,250 | 90 Apr. 17 | 2,325 | 86 Apr. 20 | 2,126 | 141 Apr. 21 | 1,965 | 152 Apr. 22 | 1,876 | 160 ---------+---------+---------