---------+---------+----------+--------+--------+----------+---------- Aug. 7 | 2,240 | 450 | 50 | 300 | | Aug. 8 | 2,260 | 450 | 50 | 225 | | Aug. 9 | 2,310 | 430 | (?) | 300 | | Aug. 10 | 2,295 | 450 | 50 | 305 | | Aug. 11 | 2,320 | 450 | 50 | 335 | 50 | Aug. 12 | 2,280 | 450 | 70 | 400 | 50 | Aug. 13 | 2,300 | 350 | 70 | 255 | 50 | Aug. 14 | 2,265 | 425 | 55 | 154 | 75 | Aug. 15 | 2,260 | 250 | 40 | 125 | 75 | Aug. 16 | 2,295 | 155 | 70 | Lost | 75 | Aug. 17 | 2,180 | 105 | 70 | 120 | 100 |Severe | | | | | | diarrhea. Aug. 18 | 2,150 | 125 | 70 | 100 | 100 |Diarrhea | | | | | | better. Aug. 19 | 2,075 | 210 | (?) | 192 | 100 |Diarrhea | | | | | | severe. Aug. 20 | 2,075 | 280 | 70 | 180 | 100 |Do. Aug. 21 | 2,165 | 260 | 50 | 225 | None |Diarrhea | | | | | | better. Aug. 22 | 2,105 | 400 | 50 | 275 | do. | Aug. 23 | 2,080 | 300 | 0 | 145 | do. |Diarrhea | | | | | | severe. Aug. 24 | 2,105 | 250 | 15 | 245 | do. |Do. Aug. 25 | 2,055 | 320 | 10 | 176 | 150 |Reflexes. Aug. 26 | 2,040 | 190 | 75 | 250 | 150 |Died at | | | | | | 1 p. m., | | | | | | without having | | | | | | showed any | | | | | | symptoms other | | | | | | than reflexes. ---------+---------+----------+--------+--------+----------+---------- SERIES C. The subjects used in these experiments were rabbits of medium size and were apparently young or at any rate were not very old. The series was planned for the study of the possible effect of diet on the toxicity of caffein when given for some time, and therefore oats were substituted for carrots, which had been fed in the previous work, as already stated. Caffein was given by mouth in the usual way, in 1 per cent solution, 100 mg. per kilo daily. Fourteen rabbits were used for these tests. Their weights were recorded daily and observations made at frequent intervals during the day.