Matters assumed, however, a very different aspect on the morning of the tenth, for the Grand Duchess was seized with symptoms exactly similar to those of the Grand Duke, whose condition by no means warranted the confidence of the physicians. Alarm spread through the villa and the guests departed in the greatest anxiety. The Cardinal alone remained, and his lack of solicitude and general indifference gave the members of the suite occasion for remark and suspicion. He assumed the air of the master of the place, and gave orders as he deemed well. Into the household he introduced some servants of his own, and ordered out his Florentine bodyguard. Urgent messages passed to and fro between him and his brother Piero de' Medici, and communications were opened with Domina Cammilla, the Cardinal's stepmother in the convent of Saint Monica. These did not allay the universal distrust. Bianca's own physician failed to diagnose her indisposition, whilst the Court physicians scouted the idea--already being translated into words--that the sudden attacks of the Grand Ducal couple were due to _poison_. What else could it be? The symptoms pointed that way and no other! On the third day tertiary fever intervened, with incessant thirst and fits of delirium, and Francesco's condition caused the gravest anxiety. Bianca was inconsolable. Unable to wait upon him, and suffering exactly as was he, she penned, propped up with pillows, a piteous appeal to the Pope, in which she craved his Holiness's prayers and benedictions, and also his fatherly protection for Francesco and herself. She said: "I do not feel at all sure of the Cardinal." The pontiff replied sympathetically, and assured her that no wrong should be done her or the Grand Duke by anybody. Francesco showed no signs of improvement, but gradually got weaker. When too late for any remedial measures to have effect, the physicians, in private conference, agreed that the cause of his seizure was poison, but--looking from the clenched hand of the dying prince to the open palm of his successor--they, in sordid self-interest, held their tongues. Who had administered the fatal drug, and when, and where, had better not be published! If by a fraternal hand, then it was no concern of theirs!