Asthma has attacked several members of the same family when forty years old, and other families during infancy. The most different diseases, such as angina pectoris, stone in the bladder, and various affections of the skin, have appeared in successive generations at nearly the same age. The little finger of a man began from some unknown cause to grow inwards, and the same finger in his two sons began at the same age to bend inwards in a similar manner. Strange and inexplicable neuralgic affections have caused parents and children to suffer agonies at about the same period of life. (14/43. Prosper Lucas tome 3 pages 678, 700, 702; Sedgwick ibid April 1863 page 449 and July 1863 page 162. Dr. J. Steinan 'Essay on Hereditary Disease' 1843 pages 27, 34.) I will give only two other cases, which are interesting as illustrating the disappearance as well as the appearance of disease at the same age. Two brothers, their father, their paternal uncles, seven cousins, and their paternal grandfather, were all similarly affected by a skin-disease, called pityriasis versicolor; "the disease, strictly limited to the males of the family (though transmitted through the females), usually appeared at puberty, and disappeared at about the age of forty or forty-five years." The second case is that of four brothers, who when about twelve years old suffered almost every week from severe headaches, which were relieved only by a recumbent position in a dark room. Their father, paternal uncles, paternal grandfather, and granduncles all suffered in the same way from headaches, which ceased at the age of fifty-four or fifty-five in all those who lived so long. None of the females of the family were affected. (14/44. These cases are given by Mr. Sedgwick on the authority of Dr. H. Stewart in 'Med.-Chirurg. Review' April 1863 pages 449, 477.)]