“The state of _anhedonia_, if I may coin a new word to pair off with _analgesia_,” he writes, “has been very little studied, but it exists. A young girl was smitten with a liver disease which for some time altered her constitution. She felt no longer any affection for her father and mother. She would have played with her doll, but it was impossible to find the least pleasure in the act. The same things which formerly convulsed her with laughter entirely failed to interest her now. Esquirol observed the case of a very intelligent magistrate who was also a prey to hepatic disease. Every emotion appeared dead within him. He manifested neither perversion nor violence, but complete absence of emotional reaction. If he went to the theatre, which he did out of habit, he could find no pleasure there. The thought of his house, of his home, of his wife, and of his absent children moved him as little, he said, as a theorem of Euclid.”(76) Prolonged seasickness will in most persons produce a temporary condition of anhedonia. Every good, terrestrial or celestial, is imagined only to be turned from with disgust. A temporary condition of this sort, connected with the religious evolution of a singularly lofty character, both intellectual and moral, is well described by the Catholic philosopher, Father Gratry, in his autobiographical recollections. In consequence of mental isolation and excessive study at the Polytechnic school, young Gratry fell into a state of nervous exhaustion with symptoms which he thus describes:— “I had such a universal terror that I woke at night with a start, thinking that the Pantheon was tumbling on the Polytechnic school, or that the school was in flames, or that the Seine was pouring into the Catacombs, and that Paris was being swallowed up. And when these impressions were past, all day long without respite I suffered an incurable and intolerable desolation, verging on despair. I thought myself, in fact, rejected by God, lost, damned! I felt something like the suffering of hell. Before that I had never even thought of hell. My mind had never turned in that direction. Neither discourses nor reflections had impressed me in that way. I took no account of hell. Now, and all at once, I suffered in a measure what is suffered there.