The next morning they soon came to an Indian village on the south shore. The Indians made signs of friendliness, and two men started toward them in a canoe which the _Adventure_ had in tow, while the flotilla drew up on the opposite side of the river. But a half-breed and some Indians jumping into a pirogue paddled out to meet the two messengers and advised them to return to their comrades, which they did. Several canoes then came off from the shore to the flotilla. The Indians who were in them seemed friendly and were pleased with the presents they received; but while these were being distributed the whites saw a number of other canoes putting off, loaded with armed warriors, painted black and red. The half-breed instantly told the Indians round about to paddle to the shore, and warned the whites to push off at once, at the same time giving them some instructions about the river. The armed Indians went down along the shore for some time as if to intercept them; but at last they were seemingly left behind. In a short time another Indian village was reached, where the warriors tried in vain to lure the whites ashore; and as the boats were hugging the opposite bank, they were suddenly fired at by a party in ambush, and one man slain. Immediately afterwards a much more serious tragedy occurred. There was with the flotilla a boat containing twenty-eight men, women, and children, among whom small-pox had broken out. To guard against infection, it was agreed that it should keep well in the rear; being warned each night by the sound of a horn when it was time to go into camp. As this forlorn boat-load of unfortunates came along, far behind the others, the Indians, seeing its defenceless position, sallied out in their canoes, and butchered or captured all who were aboard. Their cries were distinctly heard by the rearmost of the other craft, who could not stem the current and come to their rescue. But a dreadful retribution fell on the Indians; for they were infected with the disease of their victims, and for some months virulent small-pox raged among many of the bands of Creeks and Cherokees. When stricken by the disease, the savages first went into the sweat-houses, and when heated to madness, plunged into the cool streams, and so perished in multitudes.