Nothing is constant but change! All existence is a perpetual flux of "being and becoming"! That is the broad lesson of the evolution of the world, taken as a whole or in its various parts. Substance alone is eternal and unchangeable, whether we call this all-embracing world-being Nature, or Cosmos, or God, or World-spirit. The law of substance teaches us that it reveals itself to us in an infinite variety of forms, but that its essential attributes, matter and energy, are constant. All individual forms of substance are doomed to destruction. That will be the fate of the sun and its encircling planets, and of the organisms that now people the earth--the fate of the bacterium and of man. Just as the existence of every organic individual had a beginning, it will also undeniably have an end. Life and death are irrevocably united. However, philosophers and biologists hold very different views as to the real causes of this destiny. Most of their opinions are at once out of court, because they have not a clear idea of the nature of life, and so can have no adequate idea of its termination--death. The inquiry into the nature of organic life which we instituted in the second chapter has shown us that it is, in the ultimate analysis, a chemical process. The "miracle of life" is in essence nothing but the metabolism of the living matter, or of the plasm. Recent physiologists, especially Max Verworn and Max Kassowitz, have pointed out, in opposition to modern vitalism, that "life consists in a continuous alternation between the upbuild and the decay of the highly complicated chemical unities of the protoplasm. And if this conception is admitted, we may rightly say that we know what we mean by death. If death is the cessation of life, we must mean by that the cessation of the alternation between the upbuild and the dissolution of the molecules of protoplasm; and as each of the molecules of protoplasm must break up again shortly after its formation, we have in death to deal only with the definite cessation of reconstruction in the destroyed plasma-molecules. Hence a living thing is not finally dead--that is to say, absolutely incompetent to discharge any further vital function--until the whole of its plasma-molecules are destroyed." In the exhaustive justification with which Kassowitz follows up this definition in the fifteenth chapter of his _General Biology_, the natural causes of physiological death are fully described.