Most organisms meet their death through external or accidental causes--lack of sufficient food, isolation from their necessary environment, parasites and other enemies, accidents and disease. The few individuals who escape these accidental causes of death find the end of life in old age or senility, by the gradual decay of the organs and dwindling of their functions. The cause of this senility and the ensuing natural death is determined for each species of organisms by the specific nature of their plasm. As Kassowitz has lately pointed out, the senility of individuals consists in the inevitable increase in the decay of protoplasm and the metaplastic parts of the body which this produces. Each metaplasm in the body favors the inactive break-up of protoplasm, and so also the formation of new metaplasms. The death of the cells follows, because the chemical energy of the plasm gradually falls off from a certain height, the acme, of life. The plasm loses more and more the power to replace by regeneration the losses it sustains by the vital functions. As, in the mental life, the receptivity of the brain and the acuteness of the senses gradually decay, so the muscles lose their energy, the bones become fragile, the skin dry and withered, the elasticity and endurance of the movements decrease. All these normal processes of senile decay are caused by chemical changes in the plasm, in which dissimilation gains constantly on assimilation. In the end they inevitably lead to normal death.