[FIG. 192. TRANSVERSE SECTION THROUGH THE CEPHALIC REGION OF A YOUNG NEWT EMBRYO. (After Scott and Osborn.) _In.hy._ invaginated hypoblast, the dorsal part of which will form the notochord; _ep._ epiblast of neural plate; _sp._ splanchnopleure; _al._ alimentary tract; _yk._ and _Y.hy._ yolk-cells.] In the case of the group of forms in which the epiblast is early divided into nervous and epidermic layers, the former layer alone becomes involuted in the formation of the auditory pit and the lens, the external openings of which are never developed, while it is also mainly concerned in the formation of the olfactory pit. _Summary of the more important Organs derived from the three germinal layers._ The epiblast primarily gives origin to two very important parts of the body, viz. the central nervous system and the epidermis. It is from the involuted epiblast of the neural tube that the whole of the grey and white matter of the brain and spinal cord appears to be developed, the simple columnar cells of the epiblast being directly transformed into the characteristic multipolar nerve cells. The whole of the sympathetic nervous system and the peripheral nervous elements of the body, including both the spinal and the cranial nerves and ganglia, are epiblastic in origin. The epithelium (ciliated in the young animal) lining the canalis centralis of the spinal cord, together with that lining the ventricles of the brain, is the undifferentiated remnant of the primitive epiblast. The epiblast also forms the epidermis; not however the dermis, which is of mesoblastic origin. The line of junction between the epiblast and the mesoblast coincides with that between the epidermis and the dermis. From the epiblast are formed all such tegumentary organs or parts of organs as are epidermic in nature. In addition to the above, the epiblast plays an important part in the formation of the organs of special sense. According to their mode of formation, these organs may be arranged into two divisions. In the first come the organs where the sensory expansion is derived from the involuted epiblast of the medullary canal. To this class belongs the retina, including the pigment epithelium of the choroid, which is formed from the original optic vesicle budded out from the fore-brain. To the second class belong the epithelial expansions of the membranous labyrinth of the ear, and the cavity of the nose, which are formed by an involution of the epiblast covering the external surface of the embryo. These accordingly have no primary connection with the brain. 'Taste bulbs' and other terminal nervous organs, such as those of the lateral line in fishes, are also structures formed from the external epiblast. In addition to these we have the crystalline lens formed of involuted epiblast as well as the cavity of the mouth and anus, and the glands derived from them. The pituitary body is also epiblastic in origin.