To begin with, human bodies differ in nature and temperament; compounded as they admittedly are of the same elements, they are yet compounded in different proportions. I am not referring at present to sexual differences; the _male_ body is not the same or alike in different individuals; it differs in temperament and constitution; and from this it results that in different men diseases also differ both in character and in intensity; one man's body has recuperative power and is susceptible to treatment; another's is utterly crazy, open to every infection, and without vigour to resist disease. To suppose, then, that all fever, all consumption, lung-disease, or mania, being generically the same, will affect every subject in the same way, is what no sensible, thoughtful, or well-informed person would do; the same disease is easily curable in one man, and not in another. Why, sow the same wheat in various soils, and the results will vary. Let the soil be level, deep, well watered, well sunned, well aired, well ploughed, and the crop will be rich, fat, plentiful. Elevated stony ground will make a difference, no sun another difference, foothills another, and so on. Just so with disease; its soil makes it thrive and spread, or starves it. Now all this quite escapes my father; he makes no inquiries of this sort, but assumes that all mania in every body is the same, and to be treated accordingly. Besides such differences between males, it is obvious that the female body differs widely from the male both in the diseases it is subject to and in its capacity or non-capacity of recovery. The bracing effect of toil, exercise, and open air gives firmness and tone to the male; the female is soft and unstrung from its sheltered existence, and pale with anaemia, deficient caloric and excess of moisture. It is consequently, as compared with the male, open to infection, exposed to disease, unequal to vigorous treatment, and, in particular, liable to mania. With their emotional, mobile, excitable tendencies on the one hand, and their defective bodily strength on the other, women fall an easy prey to this affliction. It is quite unfair, then, to expect the physician to cure both sexes indifferently; we must recognize how far apart they are, their whole lives, pursuits, and habits, having been distinct from infancy. Do not talk of a mad person, then, but specify the sex; do not confound distinctions and force all cases under the supposed identical title of madness; keep separate what nature separates, and then examine the respective possibilities. I began this exposition with stating that the first thing we doctors look to is the nature and temperament of our patient's body: which of the humours predominates in it; is it full- blooded or the reverse; at, or past, its prime; big or little; fat or lean? When a man has satisfied himself upon these and other such points, his opinion, favourable or adverse, upon the prospects of recovery may be implicitly relied upon.