In 1650, the protector, having declared war against Spain, despatched Blake, with twenty-five men of war, to infest their coasts, and intercept their shipping. In pursuance of these orders he cruised all winter about the straits, and then lay at the mouth of the harbour of Cales, where he received intelligence, that the Spanish Plata fleet lay at anchor in the bay of Santa Cruz, in the isle of Teneriffe. On the 13th of April, 1657, he departed from Cales, and, on the 20th, arrived at Santa Cruz, where he found sixteen Spanish vessels. The bay was defended on the north side by a castle, well mounted with cannon, and in other parts with seven forts, with cannon proportioned to the bigness, all united by a line of communication manned with musketeers. The Spanish admiral drew up his small ships under the cannon of the castle, and stationed six great galleons with their broadsides to the sea: an advantageous and prudent disposition, but of little effect against the English commander; who, determining to attack them, ordered Stayner to enter the bay with his squadron: then posting some of his larger ships to play upon the fortifications, himself attacked the galleons, which, after a gallant resistance, were, at length, abandoned by the Spaniards, though the least of them was bigger than the biggest of Blake's ships. The forts and smaller vessels being now shattered and forsaken, the whole fleet was set on fire, the galleons by Blake, and the smaller vessels by Stayner, the English vessels being too much shattered in the fight to bring them away. Thus was the whole Plata fleet destroyed, "and the Spaniards," according to Rapin's remark, "sustained a great loss of ships, money, men, and merchandise, while the English gained nothing but glory;" as if he that increases the military reputation of a people, did not increase their power, and he that weakens his enemy, in effect, strengthens himself. "The whole action," says Clarendon, "was so incredible, that all men, who knew the place, wondered that any sober man, with what courage soever endowed, would ever have undertaken it, and they could hardly persuade themselves to believe what they had done; while the Spaniards comforted themselves with the belief, that they were devils, and not men, who had destroyed them in such a manner. So much a strong resolution of bold and courageous men can bring to pass, that no resistance or advantage of ground can disappoint them; and it can hardly be imagined bow small a loss the English sustained in this unparalleled action, not one ship being left behind, and the killed and wounded not exceeding two hundred men; when the slaughter, on board the Spanish ships and on shore, was incredible." The general cruised, for some time afterwards, with his victorious fleet, at the mouth of Cales, to intercept the Spanish shipping; but, finding his constitution broken, by the fatigue of the last three years, determined to return home, and died before he came to land.