Long before the appearance of man on the face of the earth, there were some happy beings well adapted to their environment, and some unhappy creatures that followed disharmonious instincts so as to imperil or to destroy their lives. Were such creatures capable of reflection and communication, plainly the fortunate among them, such as orchids and certain wasps, would be on the side of the optimists; they would declare this the best of all possible worlds, and insist that to secure happiness it is necessary only to follow natural instincts. On the other hand, the disharmonious creatures, those ill adapted to the conditions of life, would be pessimistic philosophers. Consider the case of the ladybird, driven by hunger and with a preference for honey, which searches for it on flowers and meets only with failure, or of insects driven by their instincts into the flames, only to lose their wings and their lives; such creatures, plainly, would express as their idea of the world that it was fashioned abominably, and that existence was a mistake. _II.--Disharmonies in Man_ As for man, the creature most interesting to us, in what category does he fall? Is he a being whose nature is in harmony with the conditions in which he has to live, or is he out of harmony with his environment? A critical examination is needed to answer these questions, and to such an examination the pages to follow are devoted. Science has proved that man is closely akin to the higher monkeys or anthropoid apes--a fact which we must reckon with if we are to understand human nature. The details of anatomy which show the kinship between man and the apes are numerous and astonishing. All the facts brought to light during the last forty years have supported this truth, and no single fact has been brought against it. Quite lately it has been shown that there are remarkable characters in the blood, such that, though by certain tests the fluid part of human blood can be readily distinguished from that of any other creature, the anthropoid apes, and they alone, furnish an exception to this rule. There is thus verily a close blood-relationship between the human species and the anthropoid apes. But how man arose we do not know. It is probable that he owes his origin to a mutation--a sudden change comparable with that which De Vries observed in the case of the evening primrose. The new creature possessed a brain of abnormal size placed in a spacious cranium which allowed a rapid development of intellectual faculties. This peculiarity would be transmitted to the descendants, and as it was a very considerable advantage in the struggle for existence, the new race would hold its own, propagate, and prevail.