And since we find that in the greater number of animals, in all indeed at a certain period of their existence, the channels for the transmission of the blood through the heart are so conspicuous, we have still to inquire wherefore in some creatures--those, namely, that have warm blood and that have attained to the adult age, man among the number--we should not conclude that the same thing is accomplished through the substance of the lungs, which, in the embryo, and at a time when the functions of these organs is in abeyance, Nature effects by direct passages, and which indeed she seems compelled to adopt through want of a passage by the lungs; or wherefore it should be better (for Nature always does that which is best) that she should close up the various open routes which she had formerly made use of in the embryo, and still uses in all other animals; not only opening up no new apparent channels for the passage of the blood therefore, but even entirely shutting up those which formerly existed in the embryos of those animals that have lungs. For while the lungs are yet in a state of inaction, Nature uses the two ventricles of the heart as if they formed but one for the transmission of the blood. The condition of the embryos of those animals which have lungs is the same as that of those animals which have no lungs. Thus, by studying the structure of the animals who are nearer to and further from ourselves in their modes of life and in the construction of their bodies, we can prepare ourselves to understand the nature of the pulmonary circulation in ourselves, and of the systemic circulation also. _II.--Systemic Circulation_ What remains to be said is of so novel and unheard of a character that I not only fear injury to myself from the envy of a few, but I tremble lest I have mankind at large for my enemies, so much do wont and custom that become as another nature, and doctrine once sown that hath struck deep root, and respect for antiquity, influence all men.