DEAR SIR,--I received in August your favor, wherein you give me hopes of being able to procure for me some of the big bones. I should be unfaithful to my own feeling, were I not to express to you how much I am obliged by your attention to the requests I made you on that subject. A specimen of each of the several species of bones now to be found, is to me the most desirable objects in natural history. And there is no expense of package or of safe transportation which I will not gladly reimburse, to procure them safely. Elk horns of very extraordinary size, or anything else uncommon, would be very acceptable. You will hear of my going to Europe, but my trip there will be short. I mention this, lest you should hesitate forwarding any curiosities to me. New London in Bedford, Staunton in Augusta, or Frederick County, are places from whence I can surely get them. Any observations of your own on the subject of the big bones or their history, or on anything else in the western country, will come acceptably to me, because I know you see the works of nature in the great and not merely in detail. Descriptions of animals, vegetables, minerals, or other curious things; notes as to the Indians' information of the country between the Mississippi and waters of the South Sea, &c., &c., will strike your mind as worthy being communicated. I wish you had more time to pay attention to them. I perceive by your letter, you are not unapprized that your services to your country have not made due impression on every mind. That you have enemies, you must not doubt, when you reflect that you have made yourself eminent. If you meant to escape malice, you should have confined yourself within the sleepy line of regular duty. When you transgressed this, and enterprised deeds which will hand down your name with honor to future times, you made yourself a mark for envy and malice to shoot at. Of these there is enough, you know, both in and out of office. I was not a little surprised, however, to find one person hostile to you, as far as he has personal courage to show hostility to any man. Who he is, you will probably have heard, or may know him by this description--as being all tongue without either head or heart. In the variety of his crooked schemes, however, his interest may probably veer about, so as to put it in your power to be useful to him. In which case, he certainly will be your friend again, if you want him. That you may long continue a fit object for his enmity, and for that of every person of his complexion in the State, which I know can only be by your continuing to do good to your country and to acquire honor to yourself, is the earnest prayer of one who subscribes himself, with great truth and sincerity, dear Sir, Your friend and servant. TO JAMES MADISON. AMPHILL, IN CHESTERFIELD, November 26th, 1782.