DEAR SIR,--Your favor of May 25th and June 13th have been duly received, as also the first supply of Capsicum, and the second of the same article with other seeds. I shall set great store by the Capsicum, if it is hardy enough for our climate, the species we have heretofore tried being too tender. The Galvance, too, will be particularly attended to, as it appears very different from what we cultivate by that name. I have so many grandchildren and others who might be endangered by the poison plant, that I think the risk overbalances the curiosity of trying it. The most elegant thing of that kind known is a preparation of the Jamestown weed, Datura-Stramonium, invented by the French in the time of Robespierre. Every man of firmness carried it constantly in his pocket to anticipate the Guillotine. It brings on the sleep of death as quietly as fatigue does the ordinary sleep, without the least struggle or motion. Condorcet, who had recourse to it, was found lifeless on his bed a few minutes after his landlady had left him there, and even the slipper which she had observed half suspended on his foot, was not shaken off. It seems far preferable to the Venesection of the Romans, the Hemlock of the Greeks, and the Opium of the Turks. I have never been able to learn what the preparation is, other than a strong concentration of its lethiferous principle. Could such a medicament be restrained to self-administration, it ought not to be kept secret. There are ills in life as desperate as intolerable, to which it would be the rational relief, _e. g._ the inveterate cancer. As a relief from tyranny indeed, for which the Romans recurred to it in the times of the emperors, it has been a wonder to me that they did not consider a poignard in the breast of the tyrant as a better remedy. I am sorry to learn that a banditti from our country are taking part in the domestic contests of the country adjoining you; and the more so as from the known laxity of execution in our laws, they cannot be punished, although the law has provided punishment. It will give a wrongful hue to a rightful act of taking possession of Mobile, and will be imputed to the national authority as Meranda's enterprise was, because not punished by it. I fear, too, that the Spaniards are too heavily oppressed by ignorance and superstition for self-government, and whether a change from foreign to domestic despotism will be to their advantage remains to be seen.