The most striking symptom of this disease is described as being a 'sensation of ants, crawling from the head down along the spine;' but this sensation is not always felt, for sometimes in its stead there is, rather, a very great weakness of the small part of the back, attended with pain. This is accompanied with emaciation, and occasionally, though not always, with an irregular appetite. Indeed, persons affected with this disease generally have a good appetite. There is usually little fever, or at most only a slight heat and thirst towards evening, with occasional flushings of the face; and still more rarely, profuse perspirations in the latter part of the night. But the latter symptom belongs more properly to common consumption. The sight, as I have already mentioned, grows dim; they have pains in the head and sometimes ringing in the ears, and a loss of memory. Finally, the legs become weak, the kidneys and stomach suffer, and many other difficulties arise which I cannot mention in this work, followed often by an acute fever; and unless the abominable practice which produced all the mischief is abandoned, death follows. But when many of the symptoms which I have mentioned, are really fastened upon an individual, he has sustained an injury which can never be wholly repaired. All he can hope is to prolong his days, and lengthen out his life--often a distressing one. A few well authenticated examples of persons who debased themselves by secret vice, will, I hope, satisfy those who doubt the evils of this practice. One young man thus expressed his sufferings to his physician. 'My very great debility renders the performance of every motion difficult. That of my legs is often so great, that I can scarcely stand erect; and I fear to leave my chamber. Digestion is so imperfect that the food passes unchanged, three or four hours after it has been taken into the stomach. I am oppressed with phlegm, the presence of which causes pain; and the expectoration, exhaustion. This is a brief history of my miseries. Each day brings with it an increase of all my woes. Nor do I believe that any human creature ever suffered more. Without a special interposition of Divine Providence, I cannot support so painful an existence.' Another thus writes; 'Were I not restrained by _sentiments_ of _religion_,[16] I should ere this have put an end to my existence; which is the more insupportable as it is caused by myself.' 'I cannot walk two hundred paces,' says another 'without resting myself; my feebleness is extreme; I have constant pains in every part of the body, but particularly in the shoulders and chest. My appetite is good, but this is a misfortune, since what I eat causes pains in my stomach, and is vomited up. If I read a page or two, my eyes are filled with tears and become painful:--I often sigh involuntarily.'