Two general remarks may be applied to all, interferences of the physical with the moral sanity; 1st, That it is not so much by absolute deductions of time that ill health operates upon the serviceableness of a man, as by its lingering effects upon his temper and his animal spirits. Many a man has not lost one hour of his life from illness, whose faculties of usefulness have been most seriously impaired through gloom, or untuned feelings; 3d, That it is not the direct and known risks to our health which act with the most fatal effects, but the semi-conscious condition, the atmosphere of circumstances, with which artificial life surrounds us. The great cities of Europe, perhaps London beyond all others, under the modern modes of life and business, create a vortex of preternatural tumult, a rush and frenzy of excitement, which is fatal to far more than are heard of as express victims to that system. The late Lord Londonderry's nervous seizure was no solitary or rare case. So much we happen to know. We are well assured by medical men of great London practice, that the case is one of growing frequency. In Lord Londonderry it attracted notice for reasons of obvious personal interest, as well as its tragical catastrophe. But the complaint, though one of modern growth, is well known, and comes forward under a most determinate type as to symptoms, among the mercantile class. The original predisposition to it, lies permanently in the condition of London life, especially as it exists for public men. But the immediate existing cause, which fires the train always ready for explosion, is invariably some combination of perplexities, such as are continually gathering into dark clouds over the heads of great merchants; sometimes only teasing and molesting, sometimes menacing and alarming. These perplexities are generally moving in counteracting paths: some progressive, some retrograde. There lies a man's safety. But at times it will happen that all comes at once; and then comes a shock such as no brain already predisposed by a London life, is strong enough (but more truly let us say--coarse enough) to support.