As far as can be ascertained there has not been very much investigation for the purpose of demonstrating the actual results of clinical experience regarding the antiseptic qualities of tobacco in the case of smokers, but facts, so far as they have been recorded, bear out the experiments. Rideal _Disinfection and Preservation of Food_ (London and New York, 1903) states that the investigations of Tessarini showed that tobacco smoke passed over the organisms of human cholera and pneumonia killed them in from 10 to 30 minutes. He also states that the Cigar Manufacturers Association of Hamburg reported that in the cholera epidemic of 1892 in that city, only 8 out of 5,000 employes in the cigar factories there were attacked by the disease and that, there were only 4 deaths. Professor Wenck, of the Imperial Institute of Berlin, has published an account of this cholera epidemic (see _Laucett francaise_, Paris, 1912, p. 1425). His conclusions favor the preservative action of tobacco. It was clearly shown that slightly moist tobacco was a fatal germicide for the cholera bacillus; all microbes die in it in 24 hours. The examination of cigars made in Hamburg during the epidemic showed that they were absolutely free from bacilli. Wenck asserts also that cholera microbes die in 1/2 hour, 1 hour, and 2 hours after having been placed in contact with the smoke of Brazilian, Sumatran and Havana tobacco. The fumes of tobacco will besides kill in five minutes the cholera microbes obtained from saliva. Fullerton already quoted examined a small number of mouths (74) in the Johns Hopkins Hospital at Baltimore. Of those who did not use tobacco in any form a larger percentage showed signs of dental caries and decay of an advanced stage than in the case of tobacco users. Similarly in the case of women who never used tobacco; and, although there was a much greater care and cleansing of the teeth, yet the percentage of decay and disease was higher than in the case of men using tobacco. Fullerton says, "The smoking or chewing of tobacco is decidedly germicidal. Chewing, by exercising the teeth, helps nutrition and eliminates pathological agencies both by destroying them _in situ_ and by removing them in the expectoration." Rideal (already quoted) mentions that Dr. Burney, the senior medical officer of Greenwich Hospital, London, asserts that the tobacco smoking inmates of that institution enjoyed comparative immunity from epidemics.