The facts that appear chiefly to be ascertained relative to the plague, are, 1st, That the infection is not received but by actual contact. In this particular, it would seem less formidable than several other disorders. 2. That it is communicated by certain substances, by others not, as by a woollen cloth, or rope of hemp, but not by a piece of ivory, wood, or a rope made of the date tree; nor by any thing that has been completely immersed in water. It would appear from the report of the Kahirines, that no animal but man is affected with this disorder; though, it is said, a cat passing from an infected house, has carried the contagion. 3. That persons have often remained together in the same house, and entirely under the same circumstances, of whom one has been attacked, and died; and the others never felt the smallest inconvenience. 4. That a person may be affected any number of times. 5. That it is more fatal to the young than the old. 6. That no climate appears to be exempt from it; yet, 7. that the extremes of heat and cold both appear to be adverse to it. In Constantinople it is often, but far from being always terminated by the cold of winter, and in Kahira by the heat of summer; both circumstances being, as may be conjectured, the effect of indisposition for absorption in the skin, unless it be supposed that in the latter case, it may be attributed to the change the air undergoes from the increase of the Nile. The first symptoms are said to be thirst; 2. cephalalgia; 3. a stiff and uneasy sensation, with redness and tumour about the eyes; 4. watering of the eyes; 5. white pustules on the tongue. The more advanced symptoms of buboes, fœtor of the breath, &c. &c. are well known; and I have nothing authentic to add to them. Not uncommonly, all these have successively shewn themselves, yet the patient has recovered; in which case, where suppuration has had place, the skin always remains discoloured, commonly of a purple hue.—Many who have been bleeded in an early stage of the disorder, have recovered without any fatal symptoms; but whether from that or any other cause, does not appear certain. The same operation is reported to have been commonly fatal in a late stage. It is said that embrocating the buboes continually with oil has sometimes wrought a cure; but this remedy is so difficult and dangerous for the operator, that it would appear experiments must yet be very defective. The natives of Kahira are too supine to seek for any remedy, and too bigoted to avoid the danger.