Treatise on Poisons: In relation to medical jurisprudence, physiology, and the practice of physicChristison, Robert, Sir
Science
Treatise on Poisons: In relation to medical jurisprudence, physiology, and the practice of physic
Christison, Robert, Sir
Medical jurisprudence; Toxicology
_Poisoning with the Oxalates._—Oxalic acid is one of the best examples
of a poison that acts through all its soluble chemical combinations. Dr.
Coindet and I found that the oxalates of potash and ammonia are little
inferior in energy to the acid. They do not corrode, indeed, and
scarcely ever irritate; but they produce tetanus and coma, like the
diluted acid. Half a drachm of oxalic acid neutralized with potass will
kill a rabbit in seventeen minutes; ninety grains of neutral oxalate of
ammonia will kill a strong cat in nine minutes.[423] The binoxalate of
potash, the most familiar of the salts of oxalic acid, was not tried by
us. But the preceding facts would leave little doubt of its being a
poison.
Since the last edition of this work was published several cases have
occurred which amply confirm the results of experimental inquiry. In Dr.
Babington’s case alluded to above, the greater part of the oxalic acid
had been neutralized by bicarbonate of soda [p. 176].—Mr. Tripier has
communicated the particulars of a case in which half an ounce of the
binoxalate of potash was taken by mistake for bitartrate of potash in
hot water, and caused death in eight minutes, after an attack of violent
pain and convulsions.[424]—A young woman at Bordeaux was attacked with
frequent vomiting after a dose of a drachm and a half of the same salt
dissolved in a ptisane. Next morning a similar dose caused bloody
vomiting and acute pain at the pit of the stomach; and a third dose the
following day excited delirium, more violent vomiting, and death in the
course of an hour.[425]—A girl in London swallowed about an ounce of the
same salt dissolved in hot water. Sickness and faintness ensued, with
imperceptible pulse, cold, clammy skin, rigors, scalding of the mouth
and throat, pain in the back, soreness of the eyes, redness of the
conjunctivæ, and dilatation of the pupils. Afterwards there was
reaction, with a full frequent pulse, hot skin, flushed countenance,
headache, thirst, and tenderness of the abdomen. She recovered under the
use of chalk, external heat, ether and opium draughts, leeches and
sinapisms to the belly, and carbonate of ammonia.[426]
No account has yet been published of the morbid appearances in man.
The proper antidote is sulphate of magnesia. Failing this, weak milk of
lime may be given with advantage.
_Appendix on Tartaric and Citric Acid._—These two acids may be taken in
considerable quantities without injury. Dr. Coindet and I gave a drachm
of each in solution to cats, without observing that the animals suffered
any inconvenience.[427] Dr. Sibbald, a surgeon of this place, has
informed me of an instance in which a patient of his took in twenty-four
hours six drachms of tartaric acid, having by mistake omitted the
carbonate of potass sent along with the acid to make effervescing
draughts; and yet he did not suffer any more inconvenience then the cats
on which Dr. Coindet and I experimented.
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