Treatise on Poisons: In relation to medical jurisprudence, physiology, and the practice of physicChristison, Robert, Sir
Science
Treatise on Poisons: In relation to medical jurisprudence, physiology, and the practice of physic
Christison, Robert, Sir
Medical jurisprudence; Toxicology
The actions of soda and its carbonate seem on the whole the same with
those of potash; but they are not so energetic. In one respect however
soda and its salts differ most materially from those of potash. For
while the latter, when admitted directly into a vein, act by arresting
the action of the heart, soda and its salts, according to the inquiries
of Mr. Blake, have no such effect, but cause death by obstructing the
circulation of the pulmonary capillaries, and preventing the return of
blood from the lungs to the left side of the heart. This conclusion
seems to flow from the following facts. The respiration becomes in a few
seconds laborious and soon ceases, whilst the heart continues to beat
vigorously: arterial pressure is greatly reduced, while venous pressure
is much increased owing to accumulation of blood in the right side of
the heart: after death the lungs are found congested and often full of
froth: and the heart continues contractile, very turgid in the right
side, but quite empty of blood in its left cavities.[436]
Poisoning with the caustic alkalis is rare. In 1842, a lady suffering
from inflammation of the bowels took an ounce of solution of potass by
mistake for kali-water, or a solution of bicarbonate of potash
surcharged with carbonic acid. She suffered severely at the time, and
died in a fortnight, probably of the conjunct effects of her disease and
the poison.[437] This is the only case I have found in print of
poisoning with a caustic alkali. But the effects of their carbonates
have been several times witnessed, and appear to resemble closely those
of the concentrated mineral acids.
The symptoms are in the first instance an acrid burning taste, and rapid
destruction of the lining membrane of the mouth; then burning and often
constriction in the throat and gullet, with difficult and painful
deglutition; violent vomiting, often sanguinolent, and tinging vegetable
blues green; next acute pain in the stomach and tenderness of the whole
belly; subsequently cold sweats, excessive weakness, hiccup, tremors and
twitches of the extremities; and ere long violent colic pains, with
purging of bloody stools and dark membranous flakes. So far the symptoms
are nearly the same in all cases; but in their subsequent course several
varieties may be noticed.
In the worst form of poisoning death ensues at an early period, for
example within twenty-four hours, nay even before time enough has
elapsed for diarrhœa to begin. A case of this kind, which has been very
well described by Mr. Dewar of Dunfermline, and which arose from the
patient, a boy, having accidentally swallowed about three ounces of a
strong solution of carbonate of potass, proved fatal in twelve hours
only.[438] Here death was owing to the general system or some vital
organ being affected through sympathy by the injury sustained by the
alimentary canal.
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