Treatise on Poisons: In relation to medical jurisprudence, physiology, and the practice of physicChristison, Robert, Sir
Science
Treatise on Poisons: In relation to medical jurisprudence, physiology, and the practice of physic
Christison, Robert, Sir
Medical jurisprudence; Toxicology
The _nitrate of potass_ [nitre, saltpetre, sal-prunelle], is a dangerous
poison. It has been often mistaken for the saline laxatives, especially
the sulphate of soda, and has thus been the source of fatal accidents.
SECTION I.—_Of the Chemical Tests for Nitrate of Potass._
It exists in commerce and the arts in two forms, fused and crystallized.
The fused nitre [sal-prunelle] is sold in little button-shaped masses,
spheres of the size of musket-balls, or larger circular cakes, of a
snow-white tint. The crystallized salt [sal-petre] is sold in whitish,
sulcated crystals, which are often regular and large. They are six-sided
prisms, more or lest flattened, and terminated by two converging planes.
In both forms nitre has a peculiar, cool, but sharp taste.
Its chemical properties are characteristic. In the solid form, it
animates the combustion of burning fuel, and yields nitrous fumes when
heated with strong sulphuric acid. In solution it is precipitated yellow
by the chloride of platinum, and yields, when not greatly diluted, a
crystalline precipitate with perchloric acid. The crude salt of commerce
contains chloride of sodium; and hence the odour disengaged by sulphuric
acid may be mixed with that of chlorine or hydrochloric acid gas. When
mixed with any vegetable or animal infusion by which it is coloured,
crystals may sometimes be easily procured in a state of sufficient
purity by filtration and evaporation. But if not, then the same process
must be resorted to with that formerly recommended for nitric acid (p.
143), the first step of neutralization with potass being of course
dispensed with.—A process nearly the same with this has been suggested
by M. Kramer of Milan. He proposes to free the liquid in part of animal
matter by adding acetate of lead, transmitting sulphuretted-hydrogen
through the filtered fluid to remove any excess of lead, boiling the
fluid after another filtration, and then proceeding with acetate of
silver to remove chlorides, as in the process I have adopted. In this
way he found nitre even in the blood.[447]
SECTION II.—_Of the Action of Nitrate of Potass and its Symptoms in
Man._
This substance forms an exception to the general law formerly laid down
with regard to the effect of chemical neutralization on the local
irritants. Both its acid and its alkali are simple irritants; yet the
compound salt, though certainly much inferior in power, is still
energetic. Nay, the experiment of Orfila and the particulars of some
recently published cases tend even to prove, that the action of its
alkali and acid is materially altered in kind by their combination with
one another; for, besides inflaming the part to which it is applied,
nitre has at times produced symptoms of a secondary disorder of the
brain and nerves.
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