Gentlemen, the case which the Crown undertakes to establish against the prisoner at the bar, and to support by entirely circumstantial evidence, is, or may be, shortly stated thus. They say that the prisoner having in the second week in November made up his mind that it was his interest to get rid of John Parsons Cook, deliberately prepared his body for deadly poison by the slower poison of antimony, and afterwards despatched him by the deadly poison of strychnia. No jury will convict a man of the crime thus imputed to the prisoner, unless in the first place it be made clear that he had some motive for its commission, some strong reason for desiring the death of Cook; unless, in the second place, the symptoms of the deceased before death, and the appearance presented by his body after death, were consistent with the theory of death by strychnia poison, and inconsistent with the theory of death from other and natural causes; unless, thirdly, the circumstantial evidence against him is such as to be inexplicable upon the supposition of his innocence. Now, it is under these three heads that I intend to discuss the evidence that you have heard; and it must be plain to you that if I adhere to that order and method of treating the vast amount of proof which has been laid before you, I must exhaust the whole argument, and leave myself no chance without immediate detection of evading any difficulty in the defence. [Sidenote: Serjeant Shee] Before, however, I proceed to grapple in these close quarters with the case of the Crown, as made by the Attorney-General, allow me, that you may at once see the whole scope of the address with which I have to trouble you, to claim its proper place in the discussion for a fact which, though by no means concealed from you by the Attorney-General, yet appeared to me in that address by which he at once seized upon your judgment to have been thrown too much into the shade, the fact that strychnia was not found in the body of John Parsons Cook. If he died from the poison of strychnia, he died within two hours of the administration to him of a very strong dose of it--he died within a quarter of an hour or twenty minutes of the effects of that dose being visible in the convulsions of his body; the post-mortem examination took place within six days of his death--there is not the least reason to suppose that between the time of the ingestion of the poison, if poison was taken, and the paroxysm in which he died, there was any dilution of it in the stomach, or any ejection of it by vomiting. Never, therefore, were circumstances more favourable; unless the science of chemical analysis is altogether a failure for detection of the poison of strychnia, never was there a case in which it ought to have been so easy to produce it. Now, the fact is, and it is beyond all question, that it was not found. Whatever we may think of Dr. Alfred Taylor, of his judgment, and of his discretion, we have no reason to doubt that he is a