With the acceleration of the temperature drop, there always occurs a more marked increase of the blood sugar to maximal values which may attain an average _increase of 80 percent_ and in a few cases may reach an _increase of over 100 percent_. According to that, the maximal value of about 27.5° C. [81.5° F.] is reached and is maintained for some time. It is to be observed that _as long as the temperature drop continues, in no experiment was it possible to observe a decrease in these high blood sugar values_. It is usually to be observed that a relatively rapid drop of the blood sugar values sets in when, after removal from the water, the temperature drop ceases and goes over into a temperature rise. We consider these findings to be of theoretical significance. During the isolated cooling of the neck and back of the head which was described in section III the blood sugar remained constant. In striking contrast to the increase of the blood sugar, there was never established a _corresponding glycosuria_ in the urine collected immediately after the experiment or withdrawn through a catheter, although considerable quantities of urine averaging 500 cc. were found in the bladder; in only two cases could traces of sugar (0.5 percent) be demonstrated. This paradoxical behavior can, perhaps, be explained in this manner: during the time of great blood sugar increase, a blocking of the kidneys had occurred, and that the associated urine quantities were formed before or after this blocking under reflex polyuria. Acetone and acetic acid, likewise, could not be demonstrated in the urine. The _alkali reserve_ in the arterial and venous blood was regularly very much reduced at the end of the experiments. Experiments concerning _oxygen saturation_ could not be carried out. According to the color of the venous blood withdrawn from the arm veins, the saturation of this blood must have been very greatly reduced; the blood was virtually black as it came into the syringe. Noteworthy in this connection are the autopsy findings which were undertaken directly after death. In these, the blood in the right heart appeared very dark, and in the left heart very bright red. According to this, one must calculate upon an _increase in the saturation differential between the arteries and veins_. _Sodium chloride_ and _nonprotein nitrogen_ in the blood were not clear in the blood at the end of the experiments or increased within the limit of error. _Sodium chloride in the urine_ was generally less, corresponding to a reduction of the specific gravity. On the other hand at the end of the experiments _traces of albumin_ could regularly be demonstrated _in the urine_ and moderately increased leukocytes, occasional erythrocytes, and epithelial cells in the sediments. In particular cases, _albumin casts_ were also observed. The reaction of the urine remained identical before and after the experiments virtually without exception. The studies of the bile yielded no results.